Plant Transcription Factor Database
Previous version: v3.0
Nicotiana sylvestris
WOX Family
Species TF ID Description
XP_009776871.1WOX family protein
XP_009804164.1WOX family protein
XP_009758504.1WOX family protein
XP_009783476.1WOX family protein
XP_009778688.1WOX family protein
XP_009792214.1WOX family protein
XP_009793302.1WOX family protein
XP_009793301.1WOX family protein
XP_009797138.1WOX family protein
XP_009797137.1WOX family protein
XP_009793790.1WOX family protein
XP_009771344.1WOX family protein
XP_009777417.1WOX family protein
XP_009801335.1WOX family protein
XP_009766251.1WOX family protein
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401

The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590